What truck/engine do you have? 6.0s respond very well to tuners, but may self-destruct when used a lot at the high-performance level.
6.4s will also respond well, but the DPF will have to go, and so will the warranty.
2016 Tiffin 40 QBH
2015 38RSSA, traded
2005 TK3 #1869, 10 yrs of memories,
2017 F450 KR--one more Ford is it
2009 F450 4x4-died; 2010 F450-retired