Easy answer--yes and no. I can't smoke the tires with my 450 set at 10, but it will stop the rig quickly and surely--at 9.0, less surely. But can't drag the trailer with the brakes manually set, either--haven't worried enough about this to use 4WL and try to drag.
I guarantee you that using the manual application with my 17000lb MS will result in severe neck-snapping, but no smoking tires. The results were the same with my last '07 F350.
2016 Tiffin 40 QBH
2015 38RSSA, traded
2005 TK3 #1869, 10 yrs of memories,
2017 F450 KR--one more Ford is it
2009 F450 4x4-died; 2010 F450-retired